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Beyond direct therapy, stem cells are deployed to model ALS in vitro , providing insights into disease mechanisms and revealing new therapeutic targets (63)

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147 Furthermore, administration of fluoxetine effectively inhibits SD-induced stimulation of the NLRP3 inflammasome by the AKT/STAT3 and ERK/STAT3 pathways in vivo, and SD dramatically triggers depressive-like behaviors by stimulating astrocytic P2X 7 Rs

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